Producers say the former heavyweight boxing champion will bring his one-man show, "Mike Tyson: Undisputed Truth," to the city's Air Canada Centre on Sept. 10.
Tyson details the highs and lows of his life in the 90-minute production, which has already run on Broadway and across the United States.
His wife, Kiki Tyson, wrote the show.
Acclaimed filmmaker Spike Lee directed and turned it into an HBO special that aired last November.
Tickets for the Toronto showcase go on sale July 31.