The plan will cover the costs of five drugs for rare diseases including Hunter syndrome and Pompe disease.
Health Minister Hugh Flemming said Monday the medications for such diseases aren't often covered by most drug plans and it's difficult for a province to negotiate to buy a drug for one person.
New Brunswick is partnering with Ontario to deliver the plan in an effort to increase purchasing power, Flemming said.
"They agreed to work with us with respect to purchasing so that we could get their buying power," he said.
"Over time we will be working with other governments to have a pan-Canadian plan so that there is great strength in purchasing power."
Flemming said the program is expected to cost between $1 million and $4 million per year, depending on usage, but there will be no cost to patients.
He said patients can begin applying for the drug coverage starting Aug. 1.