CN spokeswoman Lindsay Fedchyshyn says 15 grain cars went off the track near Hondo, approximately 180 kilometres northwest of Edmonton, early Sunday.
Fedchyshyn says no hazardous goods were involved and there were no injuries.
She says the train was heading south towards Edmonton.
Crews are working to repair the damage but there's no word on when the line will be running again.
The Transportation Safety Board says it has deployed a team of investigators to the site.
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