Eric Hoskins issued a statement Tuesday saying some registrations made at Service Ontario's "Be A Donor" website between March 23, 2013, and Sept. 19, this year may have resulted in incomplete or inaccurate records.
A letter will be sent to those affected by the glitch, explaining what happened and telling them how to update their information to make sure it is complete and accurate.
Hoskins says the glitch did not affect any donations of organs or tissue made by registered individuals or impact the security of anyone's information.
Hoskins says he took action to fix the problem as soon as it was discovered.
He says the website was taken down and the technical issue resolved, adding that the site is now back up and people can continue to register as organ and tissue donors.
"Organ and tissue donation is incredibly important," Hoskins said in his statement, thanking those who have registered to become donors, whether online, in person or by mail.
"One donor can save up to eight lives and help 75 more by donating tissue," he said.
The health minister says online registrations represent about 12 per cent of new donor registrations.
"While this matter was addressed successfully, as minister, I believe it is important that we continue to handle it in an open and transparent manner, because this can only strengthen the public's confidence in our health care system," he said.