Speaking on a CBC Radio phone-in show, Prentice deflected questions on the controversial section of Alberta's Human Rights Act.
Instead, he said his job as premier is to ensure the rights of all Albertans are balanced.
Civil liberties groups have protested the opt-out-clause, which allows parents to pull children out of class if sexuality, sexual orientation or religion are taught.
They say the clause is discriminatory and suggests that issues such as sexual orientation are less equal than other topics.
Prentice said he has demonstrated his commitment to equality when he voted as an MP in favour of same-sex marriage in 2005.