The Argos are awaiting results of a CT scan on the veteran receiver's right shoulder that he injured during practice Wednesday after diving for a pass. The 33-year-old watched Thursday's practice at Downsview Park in street clothes and won't play Saturday when Toronto (4-8) hosts the Edmonton Eskimos (9-4).
The test results will determine how long Durie is out but Argos head coach Scott Milanovich said the prognosis doesn't look good.
"He is going to be out for a little while," Milanovich said.
Durie suffered a broken right clavicle in Toronto's 48-15 home win over Saskatchewan on July 5 and missed seven games before returning for the Argos' 40-33 road loss to Calgary on Sept. 13.
Durie has 19 catches for 214 yards and a TD this season.
"Clearly it's a big loss," Milanovich said. "We have to possibly adjust some formations, adjust some plays that maybe were Andre-specific plays.
"What we have been doing the last day and a half is trying to figure out who can do what and what we have to do to replace that production."