Eighty-nine-year-old Leonard Mason and his 84-year-old wife Marie Mason were last seen in Scarborough on Saturday around 6 p.m. when they asked for directions back to Brampton.
They were driving a bronze Toyota Venza, licence plate BMJJ 969.
Leonard Mason was wearing a beige jacket, grey pants and dark shoes.
Marie Mason uses a wheelchair and was last seen wearing a light purple sweater. Both need heart medication and live in a senior's home at at 100 Ken Whillans Drive.
Police are concerned for their safety.
Anyone with information on the couple`s whereabouts are encouraged to contact police at (905) 453–2121, ext. 2233.