The loonie fell 0.16 of a cent to 89.36 cents as the Fed also kept its key rate unchanged at close to zero, and said it is in no hurry to hike rates.
Some traders have viewed the end of this stimulus with some trepidation since the program of massive bond purchases kept long-term rates low and helped encourage the strong rally on stock markets over the past few years.
But economic conditions have improved dramatically since the Fed first launched its initial QE program in the wake of the 2008 financial collapse. It noted Wednesday that softness in the labour market is also gradually diminishing.
Markets also looked for reassurance that the Federal Reserve will keep short-term rates low after QE ends and got it as the Fed kept the words "considerable period" in its announcement.
Meanwhile, the latest reading on American and Canadian gross domestic product also comes out this week. Markets are looking for data to show that U.S. GDP during the third quarter grew at an annualized rate of three per cent.
Traders will also find out how the Canadian economy fared during August. Statistics Canada was expected to report that gross domestic product for the month came in flat.
On the commodity markets, December crude ran up 78 cents to US$82.20 a barrel. Prices gained momentum as data showed that U.S. crude-oil inventories increased by 2.1 million barrels last week, which was slightly below expectations of an increase of 2.8 million barrels.
December copper was up for a fifth day, ahead one cent to US$3.10 a pound while December gold declined $4.50 to US$1,224.90 an ounce.