The NHL-leading Ducks sent their top two players home about 90 minutes before they hosted the New York Islanders on Wednesday night.
Perry is the NHL's top goal-scorer with 11 in the Ducks' first 13 games. He is the league's fifth-leading scorer with 15 points, and was the NHL's first star of the month for October.
Getzlaf has 14 points this season, ranking fifth in the NHL with 11 assists.
Anaheim has excelled this season despite serious injury problems. Defenceman Bryan Allen and forward Kyle Palmieri still haven't played, while defenceman Ben Lovejoy and goalie John Gibson are out for several more weeks.