The schedule also includes games played on consecutive Sundays in London for the first time.
The Miami Dolphins will return to London for a third time to face the New York Jets on Oct. 4 in an AFC East matchup.
The Jacksonville Jaguars will play the Buffalo Bills on Oct. 25. And, the following week, the Detroit Lions will be back for the second year in a row to face the Kansas City Chiefs on Nov. 1.
The Dolphins, Jaguars and Chiefs will be the "home" teams. The Bills, Chiefs and Jets will play regular-season games in the U.K. for the first time.
The league will play the last of three games this year on Sunday when the Dallas Cowboys take on the Jacksonville Jaguars. Earlier this season, the Miami Dolphins beat the Oakland Raiders and the Detroit Lions defeated the Atlanta Falcons.
This season was the first time the league played three games at Wembley. There were two games last season, and one in each of the previous six seasons.
The Jaguars have agreed to play a home game in London for four years through 2016.
The game times for next year's games will be announced at a later date.
This year's Lions-Falcons game kicked off at 1:30 p.m. in London, making it the earliest televised NFL game in the U.S. at 9:30 a.m. on the east coast and 6:30 a.m. on the west coast. All other games have started in the evening London time.
"We believe we have a great 2015 schedule that will continue to attract new fans to our sport and strengthen the bonds with our existing fans," NFL executive vice-president of international Mark Waller said in a statement. "To provide U.K. fans the opportunity to see games on consecutive weekends, to see new teams, and to attend a division game, which feature some of the most passionate rivalries in our sport, are signs of the growth and depth of our U.K. fan base."