The Shanghai Eastern Flight Training Centre will use the simulators and other CAE equipment to train pilots and cockpit crews for Airbus and Boeing passenger jets.
The other four flight simulators will be sold to undisclosed customers: three are going to a North American airline and one to an airline in China.
The equipment and services have a total list value of $120 million, but CAE says its customers are supplying some of the content in these deals.
One of the Airbus flight simulators, a Boeing simulator and other equipment will be delivered to China Eastern's training group in 2015. A second Airbus simulator will be delivered in December 2017 and the other three will be delivered later.
"With this latest purchase of five simulators, Shanghai Eastern Flight Training Centre will be operating a total of 23 CAE full-flight simulators," said Nick Leontidis, CAE's group president, Civil Simulation and Training.