In a special weather statement, the weather agency says most parts of southern Ontario are expected to see about five centimetres of snow.
The weather agency warns the incoming snow "may be a nuisance" for people heading home after work in the Toronto region.
Any issues on the road may be aggravated by winds in some areas.
The warning about the possible problems on the afternoon commute has prompted the city to remind drivers to "slow down and drive according to the conditions."
The Ministry of Transportation issued a similar reminder to "stay alert, slow down and stay in control."
As of 3 p.m., the temperature at Toronto Pearson International Airport was -4 C.
A special weather statement is also in effect for many areas surrounding Toronto, including Halton, Peel and York.
In the mid-afternoon, Halton Regional Police tweeted that some roads were getting icy and snow was beginning to accumulate.