Carlisle replaces Kevin Williams, who will retire from the automaker at the end of the year.
Williams has led GM's Canadian operations since 2010.
Carlisle was most recently GM's vice-president and general manager for its service and parts operations.
GM has more than 9,000 employees across Canada including an assembly plant in Oshawa, Ont., and CAMI Automotive in Ingersoll, Ont.
The company also builds engines at a powertrain plant in St. Catharines, Ont.