Diana Lindsay, 78, was last seen at about 8:50 a.m. on Friday at a bus stop near Bramalea Road and Father Tobin Road in Brampton.
Her family tells CBC News she was dropped off at the bus stop, as is usual, and was headed to the Brampton City Centre mall. She was supposed to pick up her granddaughter from school later in the day but never showed up.
Investigators and her family are increasingly concerned, noting this is unusual behaviour for her, and that a check of area hospitals turned up nothing.
Police say she might have boarded a bus headed for Toronto.
Lindsay is described as black, five feet tall and 150 pounds. She has short grey hair and was wearing a brown wig. She was last seen wearing a grey sweater, a long, brown winter jacket and a winter hat.
Anyone with information on her whereabouts is asked to contact 21 Division at (905) 453–2121 x2133 or Peel Crime Stoppers at 1-800-222-TIPS (8477).