So far 12 records have been broken in three days at the Hamad Aquatic Center, with five of them coming on Friday.
In the women's 200-meter backstroke, Hosszu finished in 1 minute 59.23 seconds to win gold, eclipsing American Missy Franklin's mark of 2:00.03 set in Berlin in 2011.
Emliy Seebohm of Australia came second in 2:00.13 and Sayaka Akase of Japan third in 2:02.30. Victoria's Hilary Caldwell was sixth in 2:03.06.
Hozzsu's second record came in the 100 individual medley, where she clocked 56.70 seconds, shaving 0.16 seconds off her own mark set in Dubai in September this year.
Siobhan-Marie Oconnor of Britain picked up silver in 57.83, while Seebohm took bronze in 58.19.
Olympic champion Manaudou set a new mark of 20.26 seconds in the men's 50 freestyle final, beating Roland Schoeman of South Africa's time by 0.04 seconds.
"My goal was to win but I didn't expect to break the record tonight," Manaudou said.
Italy's Marco Orsi picked up silver in 20.69 and Brazil's Cesar Cielo took bronze in 20.88.
Earlier, Denmark improved its own world record to win the women's 4x50 medley relay. The Danish quartet of Mie Nielsen, Rikke Moller Pedersen, Jeantte Ottesen and Pernille Blume finished in 1:44.04, bettering their mark of 1:45.92 set in 2013.
The U.S. took silver in 1:44.92 and France bronze in 1:45.89.
The Netherlands then ended the day by setting a world record in the women's 4x100 freestyle. Inge Dekker, Femke Heemskerk, Maud Van Der Meer and Ranomi Kromowidjojo combined to clock 3:26.53, shaving 1.89 seconds off the team's own mark set in Amsterdam in 2009.
The U.S. was second in 3:27.70 and Italy third in 3:29.48.
Mireia Belmonte Garcia of Spain picked up her fourth gold medal by winning the women's 400 freestyle. She touched in 3:55.76, ahead of Sharon van Rouwendaal and Zhang Yufei of China.
Japan's Kosuke Hagino of Japan took the men's 200 medley in 1:50.47, ahead of American defending champions Ryan Lochte, who finished in 1.51:31. Daiya Seto of Japan finished third in a time of 1:51.79.
Hungary had two more gold medallists , with Daniel Gyurta winning the 200 breaststroke in 2:01.49 and Peter Bernek taking the 400 freestyle in 3:34.32.
Ryan Cochrane of Victoria was sixth in the 400 free in 3:39.29.