RCMP say a pickup truck collided with a large transport vehicle at the Horizon site owned by Canadian Natural Resources Ltd. near Fort McMurray.
The crash sparked a fire and a man, believed to have been inside the pickup, was killed.
A company spokeswoman says operations have been suspended in the site's mining area.
Officials with the province's Occupational Health and Safety unit are investigating.
The name of the worker has not been released.
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