The annual conference is the largest of its kind in North America and a tradition for Toronto's Muslim community. It brings together speakers from around the globe which, this year, include Sheik Abdallah Bin Bayyah.
The prominent cleric recently spoke out against violent extremism and ISIS, drawing praise from U.S. President Barack Obama.
Conference organizer Summayah Poonah says she's not afraid to tackle tough subjects.
"Radicalization would certainly be a hot topic within the community and drives a lot of the discourse that happening, whether it be what happened with the fallen soldiers in Quebec or Ottawa," she told CBC News.
"I think it's our duty and our obligation as a community to really tackle these issues head on and in a real way, discussing them overtly."
British musician Sami Yusuf and U.S spoken word artist Amir Suleiman are among the performers scheduled for the entertainment segment on Saturday night.
Organizers expect some 20,000 people to attend. The conference also includes a marketplace with merchandise including fun greeting cards and T-shirts. Reviving the Islamic Spirit runs until Sunday.