RCMP say about 20 people were on board the sleigh when it was involved in a serious collision with a small car just before 7 p.m. Wednesday (near the intersection of Bayard Road and Highway 1 in Annapolis County).
Four adults from the sleigh were transported to hospital by ground ambulance with serious but non-life-threatening injuries.
One other adult from the sleigh was transported to hospital by air ambulance with what police said were undetermined injuries.
The Mounties closed the road for several hours while they investigated the incident.
There's no immediate word on any charges.