The van was last seen when it was parked at the Carvolth Bus exchange around 7:30 a.m. on Saturday.
When the owner returned at 5:30 p.m., the white 1998 Plymouth Grand Voyageur was gone.
"The interesting thing about this van is that it was equipped with a ramp to accommodate a wheelchair for one of the family members. It would cost over $5,000 to replace that piece of equipment in addition the vehicle itself. We're really just hoping someone from the public might have some information," said Langley RCMP Cpl. Holly Marks.
It's possible two children's car seats and a high-end double stroller are also in the van.
The licence plate on the van is 125 TEV.
Anyone with any information is being asked to contact Langley RCMP at 604-532-3200 or CrimeStoppers at 1-800-222-TIPS (8477).