The CN (TSX:CNR) cars carrying a variety of freight came off the rails about 160 kilometres east of Edmonton near Wainwright.
A spokesman says there are no reports of injuries.
A CN release says environmental teams are cleaning up liquid adhesive released from one of the cars, the only one to have spilled its contents.
The 114-car train was on its way to Saskatoon from Edmonton when it derailed.
CN says the train was inspected numerous times before it left the station.
An investigation is ongoing.