James B. Comey will speak at the conference at Fordham University in New York City starting at 11 a.m. ET.
Comey is expected to discuss the recent cyberattack against Sony that was believed to have been orchestrated by North Korea in retaliation for Sony's production of The Interview. The movie presents an unflattering image of North Korean leader Kim Jong-un and includes a scene of his death.
The hackers threatened violence against theatres that would screen the movie, and Sony initially decided to pull it from theatres.
The Interview was later released online and in a limited number of theatres. It grossed more than $1 million US in a limited Christmas Day release.
On Monday, Sony CEO Kazuo Hirai made his first public comments on the attack, praising employees and partners for stating up to the hackers' "extortionist efforts."
The United States has imposed sanctions against North Korea since the attacks, targeting top state officials and defence-related organizations.
North Korea has criticized the U.S. for the new sanctions.