Police were called to the motel in Owen Sound on Saturday after the manager discovered a 1 1/2-metre-long super salmon boa constrictor.
Officers were able to wrangle the slithery customer and take it to a local pet store.
Further investigation revealed the reptile's 25-year-old owner had been renting a room for the past month before travelling to Nova Scotia.
When contacted, the man told police he'd left instructions for a friend — the snake's original owner — to retrieve the boa constrictor and take it to a pet store.
The friend never showed up and the snake was left alone in the room for five or six days until it was discovered.