The former U.S. secretary of state whose husband served as president is expected to speak to about 2,000 people at the RBC Winnipeg Convention Centre at 1 p.m.
She will deliver the keynote address during the Global Perspectives series sponsored by CIBC.
Clinton now leads the Bill, Hillary and Chelsea Clinton Foundation and recently wrote Hard Choices, a memoir about her four years as secretary of state under President Barack Obama.
She has previously called Canada "an exceptional partner" to the U.S. in global peace efforts.
It has been widely speculated that Clinton is gearing up to run for the 2016 Democratic nomination for president.
Clinton is spending the evening hosting a similar talk in Saskatoon after finishing her talk in Winnipeg.