The company — known for animated movies such as "Shrek" and "Kung Fu Panda" — said Thursday that it is seeking to reduce costs and improve profitability.
DreamWorks says it will focus on six movies over the next three years — one original film and one sequel per year.
The job cuts represent 18 per cent of its workforce and are expected to be complete by the end of the year.
DreamWorks Animation SKG Inc. will take a $290 million pre-tax charge in connection with the restructuring.
Shares of the Glendale, California, company rose 3 per cent in extended trading following the announcement.