Ontario Provincial Police say Highway 6 will be closed for several hours while they investigate the collision at Chippewa Road West, south of Airport Road.
It happened just before 7 a.m., said OPP Sgt. Kerry Schmidt.
“My understanding is it’s a head-on collision,” Schmidt said. He couldn't yet comment on the road conditions at the scene.
Hamilton fire spokesperson Claudio Mostacci said when firefighters got to the scene, one vehicle was fully engulfed in flames. He couldn't say if anyone was still inside.
"You try to put it out before it gets to the gas tank," he said. By just after 7:15 a.m., crews had extinguished the flames.
An Ornge air helicopter was originally called in because of the crash, but then cancelled.
More to come.