The Alberta Law Enforcement Response Teams says the drugs include cocaine, fentanyl, methamphetamine, heroin and marijuana.
They are believed to have been supplied throughout Alberta.
The suspects include alleged suppliers, manufacturers and street-level traffickers.
A variety of weapons were also seized, along with $600,000 in cash and five luxury vehicles.
The 12 suspects face a total of 66 conspiracy, organized crime, drug and weapons-related charges.
Co-accused Donna Thanh Phoung Tran, 33, and Ronald Gene Wan Wong, 35, are alleged to have led the group.
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