"Ink and Gold: Art of the Kano" features large-scale folding screens and sliding doors designed for the residences of Japan's elite in the 16th and 17th centuries.
Other works include ink landscapes distinctive for their craggy hills and distant vistas and scenes of waves breaking in the sea.
Museum officials say the artwork spans the history of the Kano School, which was established in the 15th century and endured for nearly 400 years.
The art is drawn from imperial, national and private collections. The paintings are being presented in three rotations because of light sensitivity.
The exhibition starts Monday and runs through May 10.