Busch's No. 54 Toyota shot straight through the frontstretch and slammed head-first into an interior wall. He could not get out of the car and pointed to his right leg. He was on the ground for several minutes and was in visible pain as he grabbed his leg.
Busch was strapped to a stretcher with his right leg wrapped in a splint. He was on a stretcher as he was loaded into the ambulance.
Busch's pregnant wife, Samantha, was in tears as she dashed through the garage to reach her husband.
If Busch is seriously injured, he could sit out the Daytona 500 on Sunday. He qualified fourth driving for Joe Gibbs Racing. The race could go on without either Busch brother in the race following the suspension of older brother Kurt Busch.
Kyle Busch's car hit a portion of the wall that was not covered in the protective SAFER barrier. NASCAR drivers criticized the track on Twitter for not having the safety barriers on the concrete wall.
"Man I hope @KyleBusch is alright... It's beyond me why we don't have soft walls everywhere," six-time champion Jimmie Johnson tweeted.
"I'm genuinely furious right now. Any wall in any of the top 3 series without safer barriers is INEXCUSABLE. It's 2015," wrote Regan Smith.
Xfinity Series driver Ty Dillon said after the race no driver should have any "crazy, bad" injuries because a track did not have additional SAFER barriers.