It looked as if Kane slammed his left shoulder into the boards after he was cross-checked by Alex Petrovic with 12:11 left. Kane stayed down on the ice for a short time while a few of his teammates rushed over to confront Petrovic, and Kane then skated to the bench and went straight to the locker room.
The Blackhawks announced before the start of the second period that Kane would miss the rest of the game with an upper body injury.
Heading into Tuesday's action, Kane was tied for the NHL lead with 64 points. He leads the Blackhawks with 27 goals and 37 assists.