The company says the employees working out of the facility at 100 McDonald St. will be laid off by the end of March.
"Halliburton will be suspending operations at its Regina facility by the end of March until Canadian commodity prices recover," company spokesperson Chevalier Mayes said in an email.
"The company continues to make adjustments to its workforce based on current business conditions," Mayes added.
"We value every employee we have, but unfortunately we are faced with the difficult reality that reductions are necessary to work through this challenging market environment."
The Regina office opened with about 120 employees in 2013 to serve the oil and gas industry of southeast Saskatchewan, including the Bakken play.
Earlier this month, Halliburton said it was laying off 6,500 workers, or almost 10 per cent of its global workforce.