His wife Susan Bay Nimoy confirmed to the New York Times that her husband died Friday morning at their Los Angeles home of end-stage chronic obstructive pulmonary disease.
Nimoy said last year that he had been diagnosed with lung disease and was "doing OK."
Nimoy played Spock on the original Star Trek series from 1966 to 1969, and resurrected the iconic character in a host of subsequent movies, video games and cameo appearances spanning decades.
The character's well-known Vulcan proverb "Live long and prosper" as well as Nimoy's trademark Vulcan salute helped cement him as a pop culture icon.
More to come