The dogs are coming from Sept-Îles, a community that is struggling with a large number of strays, and will end their journey in the Laurentians.
"I've been involved in a lot of operations but this one just pulls everybody's heart strings," said Karen Morris, who works at the Sept-Îles airport.
Four pilots are donating their time, planes and fuel to take the animals to Labelle on behalf of Pilots N Paws. The organization relocates animals,from injured turtles to banned pitbulls, in need of a new home or medical care.
In the past two years, Pilots N Paws has found 130 animals in Quebec new homes.
Morris said there are many dogs running loose around the city and it's great to know the the animals rescued by Pilots N' Paws won't be euthanized.
The veterinarian for the Sept-Îles SPCA, Jennifer Blanchard, said the SPCA covers a large territory where access to clinics that spay and neuter animals are rare.
"The fact that people don't sterilize their animals as much here and leave them in the streets is a huge problem," she said.
She says it's a relief to know these animals will be getting new homes. Their departure will also make room for others, since many dogs are left at the shelter during spring and summer.
"We know that it's not going to take a long time till it's full again," she said.
Most of the pilots who work for the Pilots N Paws organization are based in BC and Ontario.
They currently have 22 volunteer pilots in Quebec.