Chelsea Yellowbird of the Samson Cree First Nation was killed outside her home in September 2011.
Three suspects were charged with first-degree murder after an extensive investigation that lasted more than two years.
Preliminary hearings for the three accused were scheduled for this week.
Shelby Minde was ordered to stand trial, while Randall Omeasoo and Wacey Applegarth opted to waive their hearing.
Yellowbird, who was 23, was slain two months after her five-year-old nephew, Ethan Yellowbird, was killed by a gun shot as he slept in a bed in the house next to his aunt's.
No date has been set for the trials.
The reserve, about 90 kilometres south of Edmonton, has struggled with drug- and gang-related violence over the years.
Three teens pleaded guilty in 2012 to manslaughter in Ethan's death. They admitted to taking turns firing a gun at the home and accidentally killing the boy.
(CHUB, The Canadian Press)