Susan Kaminskyj, who is 58, and 27-year-old Angelina Bear were last seen leaving the hospital Friday around 12:15 p.m. and 2:20 p.m. respectively.
They were both receiving treatment at the hospital.
Kaminskyj is described as Caucasian, five feet eight inches tall, weighing 115 pounds with short grey hair.
She was last seen wearing an orange and pink multi-coloured floral dress.
Angelina Bear is aboriginal, five feet four inches, 110 pounds with long black hair in braids wearing a black shirt, black and white pants with a distinct pattern and slippers.
She may also have a red shirt and blue jeans with her.
Kaminskyj may be driving a red Volkswagen Passat with Saskatchewan license plate KRLSKJ.
Anyone with information on the whereabouts of either woman is asked to contact Saskatoon police.