Premier Brad Wall says Saskatchewan will provide $250,000 to the Canadian Red Cross to help deal with what he calls a terrible catastrophe.
Manitoba Premier Greg Selinger says his province will contribute $200,000 for immediate humanitarian assistance.
Selinger says the people of Manitoba express their sorrow and condolences.
On Saturday, Nepal was hit by a 7.8 magnitude earthquake has killed more than 3,900 people and left thousands homeless.
The Foreign Affairs Department says there are 462 Canadians registered as being in Nepal, but cautioned that's only an estimate because registration is voluntary.
“I want to extend my deepest sympathies to the people of Nepal and offer some measure of hope as relatives wait to find out what has happened to family members and friends,” Wall said Monday.
"There is an enormous amount of work that needs to be done to help bring relief to Nepal and we acknowledge our role in assisting wherever we can," Selinger said.