Marc Felgar, who lives nearby on York Street in Westmount, said the noise coming from the building's ventilation system has affected his family's quality of life.
"We have to keep our windows closed," said Felgar, a member of the group Neighbours of the Glen Campus.
"The noise is constant. It's 24/seven. It's there in the morning, it's the afternoon, it's the evening. It's there when we're sleeping. We don't eat out on our back deck."
He said members have made their complaints clear in meetings with the MUHC and the company which built the hospital, SNC-Lavalin.
But Felgar says nothing has been done to mitigate the noise. Now, lawyers are involved.
Catherine Sylvestre, who filed a class-action lawsuit on behalf of the group, said close to 3,000 people living around the hospital could be affected.
Sylvestre said the claimants are demanding $5,000 per year. But she said it's not about the money.
"We hope that the problem will be fixed as soon as possible and that the damages will stop there," she said.
Neither SNC-Lavalin nor the MUHC could be reached for comment.