RCMP say the crash happened early Wednesday evening as the truck was making a left turn at an intersection and collided with the oncoming bike.
A 44-year-old man from Springbook, Alta., who was operating the motorcycle, died at the scene despite attempts by witnesses to resuscitate him.
Police say the victim was wearing a helmet.
A 30-year-old man who was in the truck was arrested at the scene for impaired driving causing death, although charges are still being sorted out.
Police have not released any names.