The 17-year-old former world No. 1 amateur will be joined by four-time LPGA Tour winner Lorie Kane of Charlottetown.
"It's really exciting to have been selected to represent Canada in the first ever Pan Am games golf competition," said Henderson. "I've had so many great experiences being a part of Golf Canada's national team program since I was 14, and now in my first year as a pro, it's a great honour to play for my country at the Pan Am Games."
The men's team is 18-year-old Austin Connelly who resides in Irving Texas, and reigning Canadian men's mid-amateur champion Garrett Rank of Elmira, Ont.
Connelly is the 10th ranked player on the World Amateur Golf Rankings.
The Pan Am golf competition runs July 16-19 at Angus Glen Golf Club in Markham, Ont.