A news release issued by CHUM said Turgeon told Quebec's health minister he was leaving yesterday.
Turgeon has accepted an offer from a United States company working in the field of health, doing research and development.
This is the second time he's resigned from his position; in March, he quit, citing disagreements with Health Minister Gaétan Barrette.
Turgeon felt that Barrette was trying to influence who was appointed to positions at the CHUM. However, he returned to his job less than a week later, with an appointment for a three-year term beginning April 1 and ending March 31.
The resignation takes effect on Sept. 4, 2015.