The OPP say that an officer tried to pull a speeding Acura over near Comber Sideroad on the eastbound side of the highway, just after 8 p.m. Sunday.
That's when police say the eastbound car fled the officer, exited the highway at Queen's Line and then got back on the eastbound Highway 401 again.
Police say that the vehicle was stopped using the rolling block manoeuvre, which involves officers boxing in a vehicle and forcing it to slow to down.
The vehicle came to a halt in the centre median near Charing Cross Road.
The 22-year-old driver was arrested.
The accused has been charged with dangerous operation of a motor vehicle, flight from police and possession of property obtained by crime under $5,000.
He also is accused of speeding, driving while under suspension and possessing an illegal licence.
The accused is due to appear in a Chatham court on Aug. 11. The charges have not been proven in court.