In an incident near Eglinton Avenue West and Alameda Avenue just before 5 a.m. ET, a male pedestrian was pinned under a car and may lose both legs. He is in stable condition.
Reporting from the scene, CBC's Linda Ward said a grey sedan ended up in a narrow alleyway wedged between buildings. A photo from the scene shows the car has extensive damage to its windshield.
The driver originally left the scene but returned, police said.
A man was taken away in handcuffs and police say a criminal investigation is underway.
An accident reconstruction team has Eglinton cordoned off between Alameda and Oakwood Avenue.
In the other incident, a woman is in hospital with life-threatening injuries after being struck by an SUV.
She was crossing Buckingham Avenue in Lawrence Park at about 9:30 p.m..
The driver remained on the scene.
There has been no word if any charges will be laid in either incident.