As Blatter took his seat, performer Simon Brodkin rose from a front-row seat to confront him.
"This is for North Korea 2026," Brodkin said as he put the bills on the desk in front of Blatter. "Thank you very much. As a North Korean football ambassador, I'm delighted that I've been able to seal the deal with FIFA and North Korea for the 2026 World Cup. It makes sense for everyone."
Brodkin then tossed the notes into the air as security led him away.
"Here we go Sepp," he said. "Thank you. Cheers Sepp. It's all there, as discussed. Thank you. Good doing business."
Blatter left the room, saying, "We have to clean here first."
He returned a few minutes later and made a quip about the incident.
"This has nothing to do with football," Blatter said. "I just called my late mother and she said, 'Don't worry, it's just a lack of education."
Brodkin was taken away by officers to a police precinct to have his details taken, Zurich police spokesman Adrian Feubli said.
The comedian also tried to disrupt a performance by Kanye West at the Glastonbury festival in Britain last month, running onto the stage during a song.