JOHANNESBURG — A new vaccine against HIV, to be tested in a trial to be launched in South Africa Wednesday, could be "the final nail in the coffin" for the disease if it is successful, scientists say.
The study, called HVTN 702, aims to
It will be the largest and most advanced HIV vaccine clinical trial to take place in South Africa, where more than 1,000 people a day are infected with HIV.
"If deployed alongside our current
"Even a moderately effective vaccine would significantly decrease the burden of HIV disease over time in countries and populations with high rates of HIV infection, such as South Africa," he said.
The vaccine being tested in HVTN 702 is based on a 2009 trial in Thailand, that was found to be 31.2
The new vaccine aims to provide greater and more sustained protection and has been adapted to the HIV subtype that predominates in southern Africa.
"HIV has taken a devastating toll in South Africa, but now we begin a scientific exploration that could hold great promise for our country,"said Glenda Gray, chief executive officer of the South African Medical Research Council.
"If an HIV vaccine were found to work in South Africa, it could dramatically alter the course of the pandemic."
Volunteers for the study, funded by NIAID, are being randomly assigned to receive either the vaccine regimen or a placebo. All participants will receive five injections over a year.
Participants who become infected with HIV in the community will be referred to local medical providers for care and treatment and will be counselled on how to reduce their risk of transmitting the virus.
South Africa has more than 6.8 million people living with HIV, but the country has had remarkable success in rolling out an HIV drug treatment program, which the government says is the largest in the world.
Life expectancy, which sank as the epidemic grew, has rebounded from 57.1 years in 2009 to 62.9 years in 2014.
Results of the vaccine study are expected in late 2020.