Police say the charges stem from two separate calls to the University of Regina campus, where evacuees are being housed.
They say a fight broke out on Friday in one of the residence towers and a 24-year-old man was allegedly assaulted by two men.
Edward Dawson Wade Keeper, who is 19, and Darian Moose, 22, are charged with assault causing bodily harm.
Early Saturday, campus security was alerted to the sounds of fighting coming from one of the rooms.
In the room, police discovered a 28-year-old woman with serious injuries.
A 29-year-old man who was staying in the same living area has been charged with aggravated assault and disobeying a court order.
Police say they are withholding the man’s name to protect the identity of the woman.
Last week, Saskatchewan agreed to welcome around 2,000 residents from the Pikangikum First Nation in Ontario as a growing forest fire rages nearby.