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do antidepressants work

I just wanted to stay home in my pjs and watch Netflix, which I did on many occasions. So inevitably, I was fired last Monday. And I don't care. In fact, I don't seem to give a shit about anything these days. And that's concerning.
My sister suffers from depression and she has been prescribed several different antidepressant medications. While she feels marginally improved, her doctor is about to start her on a new drug to see if she can do better. Why is it so hard for some patients to find the "right" antidepressant?
By Elizabeth Shimer Bowers, Everyday Health For many people, finding the right depression treatment is a trial-and-error
Drivers who take certain antidepressants, anti-anxiety or sleeping pills could be at higher risk for motor vehicle collisions