Charges are being laid against Gary Tanner, a former executive at Valeant Pharmaceuticals International Inc. and Andrew Davenport, the former CEO of Philidor Rx Services.
The "fraudulent scheme" allegedly cost investors billions of dollars.
"This is predatory pricing and we're going to make sure it is stopped," she said.
"I realize that recent events are disappointing to everyone and it is my responsibility to set the appropriate tone for the organization."
Michael Pearson had been facing criticism and recently struck a defiant tone after calls for his dismissal surfaced.
The price of Valeant shares has fallen about 70 per cent since August.
"We have a very ethical company and we're very confident in terms of the future."
Quebec's securities regulator says it hasn't launched a formal investigation into Valeant, which has its headquarters in Laval near Montreal, but is watching the situation "very seriously.''
Congressional Democrats are pressing a Republican committee chairman to force a pharmaceutical company to turn over documents
The deal Thursday comes one day after regulators approved the pill. Valeant expects the Sprout pill, Addyi, to be available