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Lynn Posluns

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More Women Get Alzheimer's, so Why Don't we Study Their Brains?

Posted: 08/03/2012 12:59 pm

I'm fortunate that no one in my immediate family has dementia -- heart and stroke seems to get us ultimately -- but I'm at the stage where I wonder if it's distraction when I can't find my car in the parking lot... or if something more serious is going on. And it scares me.

What is more frightening is learning that almost 70 per cent of new Alzheimer's sufferers will be women, but research today still focuses on men. Early Alzheimer's studies were conducted where scientists had easy access to patients, primarily on men in veteran's hospitals. But even today, at the grass roots level of research, it is the male rat that's studied because the hormones in the female rat make it too complex. Whoa.

Scientists recognized 20 years ago that a man's heart attack was different from a woman's, and addressing those differences meant a healthier outcome for both. Naturally, I wondered who was studying the female aging brain to understand where differences occurred, and what was being done about it -- I was flabbergasted to discover the real lack of female-based research. Besides, with three sons, who was going to look after me in the old folks' home?

In the U.S., someone new succumbs to Alzheimer's -- the most prevalent form of dementia -- every 68 seconds. Worldwide, there are more than 35 million people living with dementia. This number will more than triple by 2050 to more than 115 million!

When symptoms surface it is likely that the damage to the brain began 10 to 20 years prior. The cost of care in Canada alone will be more than $872 billion and 756 million hours in informal care. Women, as the major caregivers, and the most susceptible, will be hardest hit. What does that mean for me as a mother and as a daughter?

Will I become a caregiver for my mother or my in-law parents, or worse yet, will my future include grandchildren who I will not recognize? And like you, I am not alone in my fears. In a recent report a Johns Hopkins psychiatrist stated that Alzheimer's is now ahead of cancer as the most feared disease.

Once I was armed with all this great news about the future of women's brain health, I had to decide what I was going to do about it. The more I learned, the more compelled I felt to raise money to fund research to combat women's brain aging disorders. No stranger to fundraising, I created a unique campaign to raise money for the first research chair in women's aging brain health.

The more people I spoke to about the need to fund research to combat women's brain aging disorders (like Alzheimer's), the more encouraged I became. I raised $2.5 million for Baycrest, a Toronto Health Sciences Centre focused on innovations in aging, but I found that interest was not confined to Toronto. I was hearing from women across Canada, and that really got me thinking: If Canadian women were worried about the quality of their brain health as they aged, then obviously so were women all over the world.

Time to branch out... and so the Women's Brain Health Initiative was born.

Our promise is a simple one. We cannot and will not forget the women in our lives. We will not forget that women are twice as likely to become victims of aging brain disorder -- the most significant health and social crisis facing the world. We cannot forget that there is neither a theory to explain this nor a will to find one. And we will not stand idly by and wait for this oncoming disaster to strike without raising a finger to stop it.

Our mandate is therefore clear and resolute.

We will raise awareness of this imminent crisis, as well as raise money to combat it. We will focus on the stories of those affected instead of just those afflicted, and will raise a global movement inspired to combat women's brain aging disorders through investment in focused and innovative research.

It's not that we don't want to look at men's brains. We just want to level the playing field by ensuring research dollars are also focused on women in the area of aging brain health. As I build this new global foundation, I haven't lost sight of all the women who are frightened because there is a history of dementia in their families, or are frightened because they don't know where to get the information they need to make critical decisions for themselves or a loved one.

The Women's Brain Health Initiative is for women like them. Like us. Committed to sharing information about what researchers are currently studying and what their findings will mean to all of us.

For example, new research has shown that the incidence of dementia increases 140 per cent if you have a hysterectomy and both ovaries removed before natural menopause. That you're more likely to succumb to Alzheimer's if your mother had it than if your father did. And that the majority of Alzheimer's cases are lifestyle related and are not caused by a genetic predisposition.

The good news is that it's not too late to make some effective changes that will have a positive influence on how one ages. There is lots of evidence that what is good for your heart is also good for your brain. Research has shown that good eating habits, exercise, and social connectivity will all have a positive impact on your brain health.

My marketing and business background gave me the fundamentals necessary to bring together a small but dynamic team to create an innovative awareness building campaign. Designed as a movement that escalates concern over the unchecked growth of dementia and other aging brain diseases in women, the campaign reminds us of how our ability for cognitive thought is connected to every aspect of our lives.

Details about the awareness campaign are currently under wraps and will be released soon, but in the meantime to learn more about us, please visit http://womensbrainhealth.org. Together, we can make a difference for women everywhere.

 
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I'm fortunate that no one in my immediate family has dementia -- heart and stroke seems to get us ultimately -- but I'm at the stage where I wonder if it's distraction when I can't find my car in the ...
I'm fortunate that no one in my immediate family has dementia -- heart and stroke seems to get us ultimately -- but I'm at the stage where I wonder if it's distraction when I can't find my car in the ...
 
 
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04:05 PM on 08/05/2012
I was absolutely blown away about the statistics regarding Alzheimer's and women. For the past 4 months I have been sitting with a lady that was diagnosed with Alzheimer's. She can still feed herself, use the toilet and dress herself except sometimes she has a tendency to layer too much clothing. Her son who I try to help out has been her main caregiver and it has been hard on him. Seeing this up close and personal has made me more vigilant to work towards prevention as much as possible. Alzheimer's is due to oxidative stress and oxidative stress is due to free radicals! If you google oxidative stress and most common diseases you will see. Dr. Oz did a great show awhile back regarding Alzheimers and prevention, foods, etc.. and all I kept hearing about was oxidative stress, oxidative stress, so I did some research for myself to work on prevention. I found a product that has been scientically proven to reduce oxidative stress by 40%. Dr. Sanjay Gupta, also mentioned this product in his book. Go to: www.mylifevantage.com/rj54
12:05 PM on 08/06/2012
Yes there is lots of recent research on the negative impact of stress on the brain, particularly for women.
10:13 AM on 08/05/2012
I am thrilled to hear of your initiative Ms Posluns. It is wonderful that an experienced fundraiser is working on this important issue. Many people don't know health related research is done primarily on men. I don't believe many realize Alzheimer's is primarily a woman's disease. We will be allocating enormous resources on treating this disease, so let's spend more now on prevention. I am so glad you mention the estrogen and lifestyle links. I would have to disagree that there is no theory to explain the reason woman are twice as likely to be stricken with this disease. We are so wonderfully hormonally complex! There are many investigations into the neuroprotective properties of estrogen on the female brain. Search PubMed, (you may as well use our U.S.resources, apparently we aren't). The wonderful research already done on lifestyle links to Alzheimer's is not widely disseminated. Is an awareness campaign possibly a good place for allocation of resources rather than further research? I think yes. I would encourage organizations like yours to mine the data already available at a lower cost than producing more. Best of luck!
10:37 AM on 08/06/2012
Thanks for the words of encouragement and for the tip! We'll look into some of the sources that you mentioned.
12:03 PM on 08/06/2012
Thanks for the words of encouragement plus the great tip. We'll follow up on your resourcing suggestion.
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tomteboda
05:34 AM on 08/05/2012
When my great-aunt died of alzheimer's, her brain was donated to a research program at a major university. The family was told there would be no cost for this. Well, there were significant costs. We were charged for transporting her body to the university (apparently the researchers had to recover the brain there, instead of at the hospital). We were charged for no less than three post-mortem operations (for other donated organs). Two years later now we have yet to receive our beloved's ashes; the university also told us that should we want them returned, we also have to pay the cremation costs, which were, because they did it, significantly higher than the rate charged at our local funeral home.

This experience has absolutely sickened me about the state of such research.
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sabelmouse
i love to tumble , ask me why .
09:24 AM on 08/05/2012
that is mind blowing .where do they get of ?
12:15 PM on 08/06/2012
Definitely discouraging; sorry to learn your experience was so difficult. Thanks for the heads up.
11:45 PM on 08/03/2012
Simple, obvious answer. We can't find them.
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Gnomish
ego doctus ignarus
10:45 PM on 08/03/2012
OK more women get it so the argument for studying effected brains is real but why is gender even an issue? Why must everything be divisive?

Just do what's needed for a cure.
foresure
Brash and Harsh
03:12 PM on 08/05/2012
Gnomish:

Could it be that women live longer?

Let's not even consider that. It would lose its female = victim panche.
12:06 PM on 08/06/2012
It's not that we don't want to look at men's brains, but all research should take gender into account to see if there is a difference. This will result in healthier outcomes for all.